The Science Behind Rejuran: How PDRN is Revolutionizing Skin Rejuvenation
Imagine a treatment that doesn't just mask aging but repairs your skin from within—using bioactive polynucleotides to stimulate cellular regeneration and unlock your skin's natural healing potential.
What is Rejuran?
Rejuran is an innovative skin treatment that uses PDRN (Polydeoxyribonucleotide), a substance derived from highly purified salmon DNA. While the concept of injecting DNA fragments might sound complex, the science behind it is fascinating and the results speak for themselves.
The Treatment Experience
A typical Rejuran treatment takes approximately 30-45 minutes. For your comfort, we apply a topical numbing cream before the procedure to minimize any discomfort from the injections. We also offer additional pain relief options for those with heightened sensitivity.
What's more, we can combine Rejuran with complementary treatments tailored to your specific skin concerns and goals, enhancing your results and providing a truly customized approach to skin rejuvenation. Most patients experience minimal downtime, with some experiencing small injection marks or mild swelling that typically subsides within 24-48 hours.
The Science-Backed Bottom Line
As a cosmetic physician committed to evidence-based treatments, I'm particularly impressed by the growing body of research supporting PDRN's effectiveness. Rejuran isn't just another trendy treatment—it represents a significant advancement in our understanding of skin regeneration.
In a clinical trial involving 150 patients with various skin concerns, researchers noted that PDRN not only improved visible signs of aging but also enhanced the skin's overall health markers, including hydration, barrier function, and cellular turnover (Kwon et al., 2021).
Ready to Experience Rejuran?
If you're interested in learning whether Rejuran is right for you, I invite you to schedule a consultation.
We'll evaluate your specific concerns, discuss your goals, and determine if PDRN treatments align with your skincare needs.
Call us today at 021 472 665 or book online at DrSunee.com to take the first step toward healthier, more youthful skin—from the inside out.
References
Kim JH, et al. (2019). Polydeoxyribonucleotide improves peripheral tissue oxygenation and accelerates angiogenesis in diabetic foot ulcers. Journal of Dermatological Treatment, 30(6), 533-538.
Lee, K.W.A.; Chan, K.W.L.; Lee, A.; Lee, C.H.; Wan, J.; Wong, S.; Yi, K.-H. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. Int. J. Mol. Sci. 2024, 25, 8224. https://doi.org/10.3390/ijms25158224
Sun Mee Shin, Eun Joo Baek, Kwang Ho Kim, Kwang Joong Kim, Eun Joo Park. Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts. Molecular Medicine Reports 28(2) 2023 https://doi.org/10.3892/mmr.2023.13035
Nark-Kyoung Rho, Sung Tae Chung. Treatment of a Full-thickness Laceration Scar on the Forehead Using a 1,064-nm Fractional Picosecond Laser and Polynucleotide Gel Injection. Med Laser 2018;7(2):88-90 https://doi.org/10.25289/ML.2018.7.2.88
The Scientific Foundation: How PDRN Works
At its core, Rejuran works through a remarkable biological process. When PDRN is injected into the skin, it:
Activates cell regeneration by binding to specific receptors (adenosine A2A) on skin cells
Stimulates fibroblasts to produce more collagen and elastin
Improves blood circulation in treated areas
Reduces inflammation while supporting tissue repair
Clinical Evidence: What the Research Shows
Clinical studies consistently demonstrate that PDRN treatments deliver impressive results. Let's examine what the science tells us:
Study 1: Younger-Looking Skin with Improved Elasticity
PDRN (Polydeoxyribonucleotide) treatments help stimulate collagen production, which reduces fine lines and improves skin firmness. Studies show it works by repairing damaged skin cells and slowing down skin aging, leading to a smoother, more youthful complexion. [3]
Study 2: Faster Healing for Cuts, Scars & Skin Damage
PDRN has been clinically proven to speed up wound healing by promoting skin regeneration. In human trials, it helped repair skin up to 92% faster than untreated wounds, making it effective for post-surgery recovery, acne scars, and sun damage repair. [4]
Study 3: Long-Term Skin Renewal & Protection
Unlike temporary cosmetic fixes, PDRN strengthens the skin’s natural barrier over time by boosting key proteins like fibronectin and filaggrin. This means longer-lasting hydration, fewer wrinkles, and better resistance to environmental damage. [3]
What Makes Rejuran Different?
Unlike many cosmetic treatments that provide temporary results by simply adding volume or freezing muscles, Rejuran works at the cellular level to actually improve your skin's condition from within. This means:
Natural-looking results without changing facial expressions
Progressive improvement that continues even after treatment
Addresses multiple concerns simultaneously (wrinkles, elasticity, texture, and tone)
Complements other treatments you may already be using E.g. Neurotoxin, Laser or Biostimulator
Is Rejuran Right for You?
Rejuran is particularly effective for:
Fine lines and wrinkles
Skin laxity and loss of elasticity
Dull, uneven skin texture
Acne scarring
Sun-damaged skin
Thin, crepey skin around the eyes
The ideal candidate is anyone looking for natural skin rejuvenation without dramatic changes to their appearance. Many patients begin seeing results after just 2-3 sessions, with optimal results typically achieved after 3-4 treatments.
[Rejuran USA: How PDRN works. 02 Dec 2020]
© Dr S Kim 2024
